Luisa Lo Iacono

1. Ielpo D, Guzzo SM, Porcheddu GF, Viscomi MT, Catale C, Reverte I, Cabib S, Cifani C, Antonucci G, Ventura R, Lo Iacono L*, Marchetti C*, Andolina D* (2023). GABAergic miR-34a regulates Dorsal Raphè inhibitory transmission in response to aversive, but not rewarding, stimuli. PNAS. 120(32):e2301730120. doi: 10.1073/pnas.2301730120 *Corresponding authors

2. Pesca C, Lo Iacono L, Carola V (2023). The impact of childhood maltreatment on telomere length in cocaine use disorder. Journal of substance use. doi.org/10.1080/14659891.2023.2239345

3. Catale C, Martini A, Piscitelli RM, Senzasono B, Lo Iacono L, Mercuri NB, Guatteo E, Carola V (2022). Early-life social stress induces permanent alterations in plasticity and perineuronal nets in the mouse anterior cingulate cortex. European Journal of Neuroscience 56(10):5763-5783. DOI: 10.1111/ejn.15825

4. D’Addario SL, Municchi D, Mancini C, Ielpo D, Babicola L, Di Segni M, Lo Iacono L, Ferlazzo F, Cifani C, Andolina D, Ventura R. The long-lasting effects of early life adversities are sex dependent: The signature of miR-34a. Journal of Affective Disorders. 322:277-288.DOI: 10.1016/j.jad.2022.11.0

5. Catale C, Lo Iacono L, Martini A, Heil C, Guatteo E, Mercuri NB, Viscomi MT, Palacios D, Carola V (2022). Early Life Social Stress Causes Sex- and Region-Dependent Dopaminergic Changes that Are Prevented by Minocycline. Molecular Neurobiology. 59(6):3913-3932. Doi: 10.1007/s12035-022-02830-6

6. Lo Iacono L, Trentini C, Carola V. (2021). Psychobiological Consequences of Childhood Sexual Abuse: Current Knowledge and Clinical Implications. Frontiers in Neuroscience.  2:15:771511.Doi: 10.3389/fnins.2021.771511

7. Lo Iacono L, Mancini C, Babicola L, Pietrosanto M, Di Segni M, D'Addario SL, Municchi D, Ielpo D, Pascucci T, Cabib S, Ferlazzo F, D'Amato FR, Andolina D, Helmer-Citterich M, Cifani C, Ventura R (2021). Early life adversity affecting the attachment bond alters ventral tegmental area transcriptomic patterning and behavior almost exclusively in female mice. Neurobiology of stress. 15:100406. Doi: 10.1016/j.ynstr.2021.100406

8. Lo Iacono L, Ielpo D, Parisi C, Napoli G, Accoto A, Di Segni M, Babicola L, D'Addario SL, Guzzo SM, Pascucci T, Ventura R, Andolina D. (2021). MicroRNA-34a regulates 5-HT2C expression in Dorsal Raphe and contributes to the anti-depressant-like effect of fluoxetine. Neuropharmacology. 190:108559.Doi: 10.1016/j.neuropharm.2021.108559

9. Andolina D, Savi M. Ielpo D, Barbetti M, Bocchi L, Stilli D, Ventura R, Lo Iacono L, Sgoifo A, Lo Iacono L, Sgoifo A, Carnevali L. (2021). Elevated miR-34a expression and altered transcriptional profile are associated with adverse electromechanical remodeling in the heart of male rats exposed to social stress. Stress. 24(5):621-634. Doi: 10.1080/10253890.2021.1942830

10. Catale C, Bussone S, Lo Iacono L, Viscomi MT, Palacios D, Troisi A, Carola V. (2020) Exposure to different early-life stress experiences results in differentially altered DNA methylation in the brain and immune system. Neurobiology of stress. 13:100249. doi: 10.1016/j.ynstr.2020.100249.

11. Lo Iacono L, Bussone S, Andolina D, Tambelli R, Troisi A, Carola V. (2020). Dissecting major depression: the role of blood biomarkers and adverse childhood experiences in distinguishing clinical subgroups . Journal of affective disorders.  276:351-360. doi: 10.1016/j.jad.2020.07.034.

12. Babicola L, Pietrosanto M, Ielpo D, D'Addario SL, Cabib S, Ventura R, Ferlazzo F, Helmer-Citterich M, Andolina D, Lo Iacono L (2020). RISC RNA sequencing in the Dorsal Raphè reveals microRNAs regulatory activities associated with behavioral and functional adaptations to chronic stress. Brain Res. 1736:146763 doi: 10.1016/j.brainres.2020.146763.

13. Di Segni M, D'Addario SL, Babicola L, Ielpo D, Lo Iacono L, Andolina D, Accoto A, Luchetti A, Mancini C, Parisi C, D'Onofrio M, Arisi I, Brandi R, Pascucci T, Cifani C, D'Amato FR, Ventura R (2020). Xlr4 as a New Candidate Gene Underlying Vulnerability to Cocaine Effects. Neuropharmacology. 168:108019. doi: 10.1016/j.neuropharm.2020.108019.

14. Lo Iacono L, Ielpo D, Accoto A, Di Segni M, Babicola L, D'Addario SL, Ferlazzo F, Pascucci T, Ventura R, Andolina D. (2019). MicroRNA-34a Regulates the Depression-like Behavior in Mice by Modulating the Expression of Target Genes in the Dorsal Raphè. Mol Neurobiol 57(2):823-836. doi: 10.1007/s12035-019-01750-2

15. Catale C, Gironda S, Lo Iacono L, Carola V (2020). Microglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development. J Clin Med 9(2):468. doi: 10.3390/jcm9020468.

16. Bussone S, Lo Iacono L (2019). The “systems approach” to treat the brain: opportunities in developmental psychopharmacology. Dialogues in Clinical Neuroscience Vol 21, No 2. Review.

17. Catale C, Bussone S, Lo Iacono L, Carola V (2019). Microglial alterations induced by psychoactive drugs: A possible mechanism in substance use disorder? Semin Cell Dev Biol. 94:164-175. doi: 10.1016/j.semcdb.2019.03.008. Review.

18. Di Segni M, Andolina D, D'Addario SL, Babicola L, Ielpo D, Luchetti A, Pascucci T, Lo Iacono L, D'Amato FR, Ventura R (2019). Sex-dependent effects of early unstable post-natal environment on response to positive and negative stimuli in adult mice. Neuroscience. 413:1-10. doi: 10.1016/j.neuroscience.2019.06.016.

19. Lo Iacono L, Catale C, Martini A, Valzania A, Viscomi MT, Chiurchiù V, Guatteo E, Bussone S, Perrone F, Di Sabato P, Aricò E, D'Argenio A, Troisi A, Mercuri NB, Maccarrone M, Puglisi-Allegra S, Casella P, Carola V (2018). From traumatic childhood to cocaine abuse. The critical function of the immune system. Biological Psychiatry 15;84(12):905-916. doi: 10.1016/j.biopsych.2018.05.022.;

20. Andolina D, Di Segni M, Accoto A, Lo Iacono L, Borreca A, Ielpo D, Berretta N, Perlas E, Puglisi-Allegra S & Ventura R (2018). MicroRNA-34 Contributes to the Stress-related Behavior and Affects 5-HT Prefrontal/GABA Amygdalar System through Regulation of Corticotropin-releasing Factor Receptor 1. Molecular Neurobiology  55(9):7401-7412; doi: 10.1007/s12035-018-0925-z.

21. Lo Iacono L & Carola V. (2018) The impact of adolescent stress experiences on neurobiological  development. Seminars in Cell and Developmental Biology 77:93-103; doi: 10.1016/j.semcdb.2017.09.040.

22. Latagliata EC, Lo Iacono L, Chiacchierini G, Sancandi M, Rava A, Oliva V, Puglisi-Allegra S. (2017) Single Prazosin Infusion in Prelimbic Cortex Fosters Extinction of Amphetamine-Induced Conditioned Place Preference. Frontiers in Pharmacology 10;8:530 doi: 10.3389/fphar.2017.00530.

23. Lo Iacono L, Valzania A, Visco-Comandini F, Aricò E, Viscomi MT, Castiello L, Oddi D, D’Amato FR, Bisicchia E, Ermakova O, Puglisi-Allegra S, Carola V (2016). Social threat exposure in juvenile mice promotes cocaine-seeking by altering blood clotting and brain vasculature. Addiction Biology 22(4):911-922. doi: 10.1111/adb.12373

24. Lo Iacono L, Valzania A, Visco-Comandini F, Viscomi MT, Felsani A, Puglisi-Allegra S, Carola V (2016). Regulation of nucleus accumbens transcript levels in mice by early-life social stress and cocaine. Neuropharmacology, 103:183-94. doi: 10.1016/j.neuropharm.2015.12.011.

25. Lo Iacono L, Visco-Comandini F, Valzania A, Viscomi MT, Coviello M, Giampà A, Roscini L, Bisicchia E, Siracusano A, Troisi A, Puglisi-Allegra S, Carola V (2015) Adversity in childhood and depression: linked through SIRT1. Translational Psychiatry, 5, e629; doi:10.1038/tp.2015.125.

26. Lo Iacono L, Boczkowski J, Zini R, Salouage I, Berdeaux A, Motterlini R, Morin D (2011). A carbon monoxide-releasing molecule (CORM-3) uncouples mitochondrial respiration and modulates the production of reactive oxygen species. Free Radical Biology and Medicine 1;50(11):1556-64. doi: 10.1016/j.freeradbiomed.2011.02.033

27. Ferreira TA, Lo Iacono L, Gross, CT (2010). Serotonin receptor 1A modulates actin dynamics and restricts dendritic growth in hippocampal neurons. European Journal of Neuroscience. 32(1):18-26. doi: 10.1111/j.1460-9568.2010.07283.x

28. Zanettini C, Carola V, Lo Iacono L, Moles A, Gross C, D’Amato FR (2010). Postnatal handling reverses social anxiety in serotonin receptor 1A knockout mice. Genes Brain and Behavior. 9(1):26-32. doi: 10.1111/j.1601-183X.2009.00531.x

29. Lo Iacono L, Gross C (2008). Alpha-Ca2+/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice. Journal of neuroscience 11;28(24):6250-7. doi: 10.1523/JNEUROSCI.5219-07.2008.

30. Tsetsenis T, Ma X, Lo Iacono L, Beck SG., Gross C (2007). Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus. Nature Neuroscience 10(7):896-902. doi: 10.1038/nn1919.

Pubblicazione di Capitoli

1. Andolina D, Lo Iacono L, Ventura R (2021). Modelli animali per lo studio della depressione. Sez.1 – Cap.2 Vol. “Neuroscience psichiatriche e computazionali” Ed. Minerva Medica